Pseudomonas Aeruginosa Essays - Gram-negative Bacteria,

Pseudomonas Aeruginosa Pseudomonas aeruginosa Research Paper Julie Johnson Pseudomonas aeruginosa is a versatile gram negative bacterium that grows in soil, marshes, and coastal marine habitats, as well as on plant and animal tissues. People with cystic fibrosis, burn victims, individuals with cancer, and persons infected with HIV are particularly at risk of disease resulting from Pseudomonas aeruginosa. Unlike many environmental bacteria, Pseudomonas aeruginosa has a remarkable capacity to cause disease in susceptible hosts. It has the ability to adapt to and thrive in many ecological niches, from water and soil to plant and animal tissues. The bacterium is capable of utilizing a wide range of organic compounds as food sources, thus giving it an exceptional ability to colonize ecological niches where nutrients are limited. Pseudomonas aeruginosa can produce a number of toxic proteins, which not only cause extensive tissue damage, but also interfere with the human immune systems defense mechanisms. These proteins range from potent toxins that enter and kill host cells at or near the site of colonization to degradative enzymes that permanently disrupt the cell membranes and connective tissues in various organs. In people with cystic fibrosis the most serious complication is respiratory tract infection by the ubiquitous bacterium Pseudomonas aeruginosa. CF is one of the most common fatal genetic disorders in the United States, affecting about 30,000 individuals. A comparable number of people in Europe also have CF. It is most prevalent in the Caucasian population, occurring in one of every 3,300 live births. The gene involved in cystic fibrosis was identified in 1989. Located on human chromosome 7, it codes for a protein called the cystic fibrosis transmembrane conductance regulator (CFTR). This protein, normally produced in a number of tissues throughout the body, regulates the movement of salt and water in and out of these cells. The abnormality in the CFTR gene alters the CFTR protein in people with cystic fibrosis. As a result, one hallmark of CF is the presence of a thick mucus secretion which clogs the bronchial tubes in the lungs and plugs the exit passages from pancreas and intestine s, leading to loss of function of these organs. Progressive lung disease is the predominant cause of illness and death in people with CF. Mucus blocks the airway passages and results in a predisposition toward chronic bacterial infections. Although the genetic defect underlying CF has been characterized, exactly how and why individuals become infected with Pseudomonas is unknown. The lungs of most children with CF become colonized by Pseudomonas aeruginosa before their 10th birthday. Chronic infection with these bacteria reduces an individuals quality of life, causing acute symptoms of cough, sputum production, and inflammation, which causes repeated exacerbations or episodes of intense breathing problems. Eventually leading to scarring and destruction of lung tissue and, ultimately, death. While it is clear that antibiotic therapy directed against these organisms lengthens the life span of individuals with CF, increasing antibiotic resistance develops. Although antibiotics can decrease the frequency and duration of these attacks, the bacterium establishes a permanent residence and can never be completely eliminated from the lungs. Management of cystic fibrosis lung disease requires a multipronged approach. Outpatient management of pulmonary exacerbation usually includes a combination of 2 IV antipseudomonal antibiotics (an aminoglycoside plus a beta-lactam), appropriate antimicrobial treatment, effective airway clearance, optimization of nutritional status, and anti-inflammatory therapies. Additionally, prevention of respiratory viral disease and avoidance of exposure to irritants, such as smoke, is recommended. Usual duration of therapy is 14 to 21 days, and clinical response is assessed by physical exam, pulmonary function tests, nutritional status, and exercise tolerance. Microbial eradication is not a therapeudic end point. Choice of antibiotics should be based on culture and sensitivity of the sputum. Emergence of antibiotic-resistant species, such as Pseudomonas aeruginosa, has required close monitoring of antibiotic susceptibility patterns and strict infection-control policies. Administration of chronic intermittent inhaled antipseudomonal therapy (tobramycin solution for inhalation), over a 6 month period was shown to improve FEV by 11.9%, decrease the bacterial density, and reduce hospitalization in CF patients chronically infected with Pseudomonas aeruginosa. Following 92 weeks of therapy with inhaled tobramycin, the mean % change in FEV was 4.7% above baseline. There was no increase in the utilization of antipseudomonal therapy despite an increase in MIC at

Using a Sample GRE Essay Question to Improve Your Score

Using a Sample GRE Essay Question to Improve Your ScoreYou can use a sample GRE essay question to help you find out how well you are doing. This is a method that can really help you improve your scores and is also one of the best ways to get feedback on what you need to work on if you haven't taken the test.It is important to remember that all of the GRE practice questions you use should come from the same sample. Not only will this make your scores better, but it will also give you a good idea of what areas of your writing you need to focus on. There are many different tips for finding a good practice GRE question and most of them revolve around taking the test as many times as possible to get a feel for the format.Many students find that it helps to take the exam multiple times because they find the format of the test is too confusing for just one time. This way, they have the opportunity to look at a number of different topics and learn how to prepare their answers based on the fo rmat. Most of the questions involve testing how well you can organize a response.It is very important to write out each of the essay questions you encounter so that you have a written solution for each of them. Taking the exam multiple times can cause the questions to be too hard to read and most students find that it is easier to just mark the answer incorrectly than to try to think of the right answer. This way, they can just concentrate on getting the question right.The most common question you will encounter when studying for the GRE is the 'Shoot the Pilot' question. This is when you are asked to present an argument for why a specific thesis statement should be accepted. In order to get the highest score possible, you will need to use examples and supporting evidence.Using a sample GRE essay question to help you study is an excellent way to prepare for this question because you are given many different examples to work with. This allows you to use your own information as well a s other people and come up with a convincing argument.A sample GRE essay question that most students find useful is the 'Find out how well you do on exam days'. This question asks you to identify how well you perform on exam days and this is the most commonly used test format. If you're not aware of what a typical test may consist of, you should take a look at sample GRE questions before you take the test.Since the passage that is studied for the GRE includes a number of very long and difficult questions, it is possible to come across something you are confused about. Studying for this type of question on the internet can help you see the question and answer. This will allow you to go back to the sample and figure out the correct answer before sitting down to take the actual test.

Biography of Georges Seurat, Father of Pointillism

Biography of Georges Seurat, Father of Pointillism Georges Seurat (December 2, 1859 – March 29, 1891) was a French painter of the post-impressionist era. He’s best known for developing the techniques of pointillism and chromoluminarism, and one of his iconic paintings was instrumental in ushering in the era of Neo-Impressionism. Fast Facts: Georges Seurat Full Name:  Georges-Pierre SeuratOccupation: ArtistKnown For: Creating the techniques of pointillism and chromoluminarism, with scenes emphasizing smooth lines and colors blended by visual observation, not mixed pigmentsBorn: December 2, 1859 in Paris, FranceDied: March 29, 1891 in Paris, FrancePartner: Madeleine Knobloch (1868-1903)Children: Pierre-Georges (1890-1891), unnamed child (died at birth, 1891)Notable Works:  Bathers at Asnià ¨res, A Sunday Afternoon on the Island of La Grande Jatte, The Channel of Gravelines, Petit Fort Philippe Early Life Georges Seurat was the third and youngest child of Antoine Chrysostome Seurat and Ernestine Seurat (nà ©e Faivre). The couple already had a son, Émile Augustin, and a daughter, Marie-Berthe. Thanks to Antoine’s success in property speculation, the family enjoyed considerable wealth. Antoine lived separately from his family, visiting them weekly rather than living under the same roof. Georges Seurat began studying art early; his first studies occurred at the École Municipale de Sculpture et Dessin, an art academy run by the sculptor Justin Lequien near the Seurat family’s home in Paris. In 1878, he moved to the École des Beaux-Arts, where his studies followed the typical courses of the time, focusing on copying and drawing from existing works. He finished his artistic training in 1879 and left for a year of military service. Early Career and Innovation When he returned from his military service, Seurat shared a studio with his friend and fellow artist Edmond Aman-Jean, where he worked to master the art of monochrome drawing. In 1883, he had his first work exhibited: a crayon drawing of Aman-Jean. The same year, he spent most of his time working on his first major painting, Bathers at Asnià ¨res. Final Study for Bathers at Asnieres by Georges Seurat. Francis G. Mayer / Getty Images Although Bathers at Asnià ¨res had some impressionistic influences, specifically in its use of light and color, it broke from that tradition with its textures and outlined figures. His process also departed from impressionism, as he sketched out several drafts of the piece before actually starting to work on the final canvas itself. The painting was rejected by the Paris Salon; instead, Seurat showed it in May 1884 at the Groupe des Artistes Indà ©pendants. Among that society, he met and befriended several other artists. However, the society’s disorganization soon frustrated Seurat and some of his friends, and together, they split from the Indà ©pendants to create a new artists’ society of their own, called the Socià ©tà © des Artistes Indà ©pendants. Georges Seurat was heavily influenced by contemporary ideas about color theory, which he tried to apply to his own works. He subscribed to the idea of a scientific approach to painting with color: that there was a natural law to the way colors worked together to evoke emotion in art, similar to how musical tones worked together in harmony or dissonance. Seurat believed that he could create a new artistic â€Å"language† using perception, color, and lines. He called this theoretical visual language â€Å"chromoluminarism;† today, it’s included under the term divisionism, referring to how the technique requires the eye to combine adjacent colors, rather than the artist mixing pigments before painting. Family Life and Famous Work Right on the heels of the debut of Bathers at Asnià ¨res, Seurat began work on his next piece, which would come to be his most famous and enduring legacy. A Sunday Afternoon on the Island of La Grande Jatte depicts members of different social classes all spending a leisure afternoon at a park on the waterfront of the Seine in Paris. Sunday on the Island of la Grande Jatte by Georges Seurat. To create the painting, Seurat used his color and pointillism techniques, using tiny dots of individual colors overlapping and adjacent to each other so that they would be â€Å"blended† by viewers’ eyes, rather than mixing the paints themselves. He also prepared for the painting by spending significant time at the park he depicted, sketching his surroundings. The resulting painting measures 10 feet wide and currently is displayed at the Art Institute of Chicago. A smaller, related study, Study for A Sunday Afternoon on the Island of La Grande Jatte, resides in New York City in the Metropolitan Museum of Art. Although Seurat never married, he had a significant romantic relationship with Madeleine Knobloch, an artist’s model. She was the model for his 1889/1890 painting Jeune femme se poudrant, but they took pains to conceal their relationship for some time. In 1889, she moved into Seurats apartment, and she became pregnant sometime in 1889. The couple moved to a new apartment to accommodate their family, and Knobloch gave birth to their son, Pierre-Georges, on February 16, 1890. Final Years and Legacy During the summer of 1890, Seurat spent most of his time at the commune of Graveline, along the coast. He was incredibly prolific that summer, producing four canvas paintings, eight oil panels, and several drawings. Out of his works from that time period, the most notable was his painting The Channel of Gravelines, Petit Fort Philippe. The Channel at Gravelines, in the Direction of the Sea by Georges Seurat. Francis G. Mayer / Getty Images Georges Seurat began working on another painting, The Circus, but he did not live to continue innovating and working. In March 1891 he fell ill, and on March 29, he died at his parents’ home in Paris. The nature of the illness that caused his death is unknown; theories include meningitis, diptheria, and pneumonia. Whatever the illness was, he passed it on to his son Pierre-Georges, who died weeks later. Madeleine Knobloch was pregnant at the time, but their second child did not survive long after birth. Seurat was buried on March 31, 1891 at Cimetià ¨re du Pà ¨re-Lachaise, the largest cemetery in Paris. He left behind a legacy of significant artistic innovation, despite dying at the very young age of 31. Seurat’s use of color and his work with pointillism have been his most enduring artistic legacies. In 1984, nearly a century after his death, Seurat’s most famous painting became the inspiration for a Broadway musical by Stephen Sondheim and James Lapine. Sunday in the Park with George is inspired by the painting, and the first act of the musical depicts Seurat himself in a highly fictionalized way, imagining his creative process. The musical focuses more on his artistic pursuits but also does depict a fictionalized version of his personal life, notably in the character of his mistress â€Å"Dot,† who seems to be an avatar for Madeleine Knobloch. Art students still study Georges Seurat today, and his influence on other artists began not long after his death. The cubist movement looked at his linear structures and form, which then influenced their ongoing artistic developments. And of course, even young children in the modern world learn about pointillism, usually through A Sunday Afternoon. Despite his short life, Georges Seurat established himself as a key and permanent player in the art world. Sources Courthion, Pierre. â€Å"Georges Seurat: French Painter.† Encyclopaedia Britannica, https://www.britannica.com/biography/Georges-Seurat.Georges Seurat, 1859–1891. New York: Metropolitan Museum of Art. 1991Jooren, Marieke; Veldink, Suzanne; Berger, Helewise.  Seurat. Krà ¶ller-Mà ¼ller Museum, 2014.

Write a short biography on James McGill Buchanan, an analysis of his Essay

Write a short biography on James McGill Buchanan, an analysis of his economic theories, and his contributions to the welfare of society - Essay Example He was also, in 1963, at the senior most position at the Southern Economic Association; shortly after, in 1971, at the American Economic Association he served as vice president, and then for two years, 1983 and 1984, in a similar position at the Western Economic Association (â€Å"James M. Buchanan†). Buchanan coauthored ‘The Calculus of Consent’ with Gordon Tullock as one of the products of thinking cultivated by reading a German article by Knut Wicksell, a Swedish economist(DiLorenzo 180). Wicksell was of the idea that the benefits taxpayers received should be directly linked to the taxes they pay. This implied that taxes and government spending would be agreed upon and validated, as opposed to the conventional view of the 1940s and even the current view. The book ‘The Calculus of Consent’ revised Wicksell’s idea, and referred to it as ‘workable unanimity’, as they thought it impractical. This together with ‘The Economics of Democracy’, a book by Anthony Down, gave birth to the field of public choice. Buchanan and Tullock even went on to initiate an academic journal- Public Choice. At this time, he raised dissimilarity between two levels of public choice; the first being during the making of the constitution and the second being after the constitution has been implemented. He has attempted to convert his fellow economists to this line of thinking, where they should focus more on the first level rather than on the second level as mere political players. To push this ideology farther, he published a journal- Constitutional Economics (â€Å"James M. Buchanan†). Buchanan also believed that welfare economics is skewed as costs are subjective. He pointed this out in an unusually ardent economics book- Costs and Choice. This was the book that he considered most essential yet to the Nobel Committee it was ‘The Calculus of Consent’. In the book, Buchanan’s aim

Marketing Management Essay Example | Topics and Well Written Essays - 250 words - 9

Marketing Management - Essay Example Despite its effectiveness, Warfarin monitoring is a major drawback, whereby blood is tested to determine international normalised ratio (INR) for proper dosage. This makes the process of administering the drug slow and thus its effect on an individual takes time. Research shows that increased intake of Warfarin causes a decrease in bone density, which eventually leads to osteoporoses. Pharmaceutical company Boehringer Ingelhiem have solved some of the problems caused by Warfarin with the introduction of Pradaxa. Mueller states, â€Å"Pradaxa is an oral drug that is unique in that it blocks the protein clotting thrombin† (Mueller, web). Its approval by US Food and Drug Administration (FDA) for prevention of stroke in patients with non-valvular atria fibrillation was also a major development. Pradaxa blood thinner does not require frequent monitoring for (INR) but offers good results in terms of efficacy. Though Pradaxa costs ten times more than Warfarin, the cost of monitoring required in Warfarin makes it more expensive than Pradaxa. One major disadvantage of Pradaxa is that its blood thinning effect cannot be reversed once administered unlike in Warfarin which is reversible. Since Pradaxa contains tartaric acid, it lowers the PH levels of Patients under it and in return leads to increased gastrointestinal bleeding. Approval of Xarelto by Bayer Company will be a further improvement of Warfarin and Pradaxa. Research shows that Xarelto does not need monitoring or dose adjustments, it can be used across all ages, and it is a non-inferior and has a superior efficacy. However there is increased bleeding in Xarelto

Price Elasticity Essay Example for Free

Price Elasticity Essay Using the calculation of: price elasticity of demand= (percentage change in quantity)/(percentage change in price) When the percentage change in the quantity that is demanded is greater than the percentage change in the price, the resulting absolute value of the calculation will be greater than 1. The first two products, Barnes and Noble books and Coca-Cola, will therefore have an elastic demand classification. When the percentage change in the quantity that is demanded is less than the percentage change in the price, the resulting absolute value of the calculation will be less than 1. The last three products of Cigarettes, Beer, and Gasoline; will therefore have an inelastic demand classification. (R. Glen Hubbard, 2012) Explain the implications of those classifications on tax revenue collections when the per-unit tax increases as opposed to decreases. When the products are inelastic, an increase in price from the higher duty will lead to a small decrease in demand which is not enough to offset the higher tax that is raised on each unit. Basically, tax revenue collections will therefore rise. The tax revenue collections will fall when that price decreases. They move in the same direction. When the products are elastic, an increase in price from the higher duty would lead to a fall in tax revenue collections. Alternately, when the price decreases, it would lead to a rise in the tax revenue collections. The relationship here is an inverse one. (R. Glen Hubbard, 2012) Using those classifications, make some assumptions regarding tax incidence. For instance, will buyers or sellers pay a larger portion of the tax per unit? Explain. If the product is price inelastic to the consumer (if price rose, a small demand loss would be accounted for by the extra revenue), the seller is able to pass the entire or most of the burden of the tax on to the buyer. The tax incidence here falls on the buyer. If the seller is unable to raise prices because the product is price elastic (if prices rose, more demand would be lost than extra revenue gained), the seller then has to bear the burden of the tax or face decreased revenues. The tax incidence here falls to the seller. In this scenario, the burden would likely continue to flow further back to the factors of production. (Wikipedia, 2013) Conclude, based on the elasticity classifications, their effect on tax revenue and tax incidence, and which goods the government would prefer to tax. The government would prefer to tax products that are usually inelastic. The reason for this is that the quantity demanded of inelastic goods is proportionally smaller than the increase or decrease in the change in price†¦they are less responsive. Therefore the government will place taxes on these goods and they will acquire higher tax revenues. The seller basically does not care that much as they simply place most of the burden of these taxes onto the buyer. Bibliography R. Glen Hubbard, A. P. (2012). Microeconomics, 3rd edition. Upper Saddle River: Prentice Hall. Wikipedia. (2013, April 6). Tax Incidence. Retrieved 9 21, 2013, from http://en.wikipedia.org/wiki/Tax_incidence

The Development Of Desire :: essays research papers fc

The Development of Desire The development of the male warrior, throughout literature, has a direct relationship with the development of western civilization. The attributes a warrior holds, fall respectively with the attributes that each society held as valuable. These characteristics, started by societies ideals, become the warrior's only reasons for continuing their heroics. The ideals however do change with each warrior. At the beginning we have a warrior with one mission, which later the warriors become more challenged and have to change ideas and concepts to continue. The evolution of the warriors desires becomes the complex ideals that western civilization develops over time. With this progression of civilization, from simple to complex ideals, so will the evolution of the ideals and desires of our heroes change from simple to complex.   Ã‚  Ã‚  Ã‚  Ã‚  Odysseus is a man who is both strong and smart, but most known not for the brawn of his body, but the wits of his brain. A man who is loved in every country, but Trojan, and could stay where ever he chooses, his sailors knew this to be true as one bench mate to the next, â€Å"It never fails. He is welcome everywhere: hail to the captain when he goes ashore!† (Homer 166). The irony falls as Odysseus only desires his homeland. †Begin when all the rest who left behind them headlong death in battle or at sea had long ago returned, while he[ Odysseus] alone still hungered for home and wife† (Homer 1).   Ã‚  Ã‚  Ã‚  Ã‚  Odysseus has many opportunities to end his journeys and start a new life. For instance, if he desired, Odysseus was able to stay with Kalypso who wanted him forever, â€Å"Her ladyship Kalypso clung to him in her sea-hollowed caves- a nymph, immortal and most beautiful, who craved him for her own† (Homer 1). Kalypso knows even though she has Odysseus in her home, he is not hers to have. â€Å" Son of Laertes, versatile Odysseus, after all these years with me, you still desire your old home? Even so I wish you well†( Homer 87). To which Odysseus replies, â€Å"...Yet, it is true, each day I long for home, long for the sight of home...† (Homer 87). Another chance for Odysseus to start a new life is offered by the king of the Phaecians to marry his daughter and live there; â€Å"...seeing the man that you are, seeing your thoughts are my own thoughts-my daughter should be yours and you my son-in-law, if you remained. â€Å"( Homer 120). In each case, Odysseus, only wants to return to his wife Penelope, his son, and most of all his homeland.